X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
about
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseDeficiency of the copper chaperone for superoxide dismutase increases amyloid-β productionAlternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.An overview of APP processing enzymes and products.Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1.Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.Deletions flanked by breakpoints 3 and 4 on 15q13 may contribute to abnormal phenotypes.Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.Serotonin 6 receptor controls Alzheimer's disease and depressionHyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's diseaseX11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.X11/Mint genes control polarized localization of axonal membrane proteins in vivoX11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.Cell biology, regulation and inhibition of beta-secretase (BACE-1).Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.Amyloid precursor protein processing and Alzheimer's diseaseThe role of lipoprotein receptors on the physiological function of APP.APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins.Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.Novel mediators of amyloid precursor protein signaling.Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.Calmodulin Binding Proteins and Alzheimer's Disease.Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearanceIncreased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain.Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.Association of AMD-like retinopathy development with an Alzheimer's disease metabolic pathway in OXYS rats.Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease.
P2860
Q26269934-D7DFDCD0-1F49-4F52-9F22-5B2BB5A1A123Q28289956-771EEC01-2664-426D-AB30-6EE83563E8C6Q30511181-1CCB16E0-67DA-4421-AC2E-4810AD13D441Q33927819-37BB0F45-9D48-4A50-800B-97596FF6E4A8Q33983121-FB8EDC51-8664-44EE-A461-7271FE25BFF7Q34384688-704B704A-BF7E-4B94-B2AF-BD3EE924C4DEQ34494853-95266893-0F67-45B6-9F7F-2AC388FDE045Q34873887-C4790C08-9E2F-4134-BF5E-4BEA4C8D3A2AQ34958958-9BF4D095-5C4B-4CE2-9ACA-40782E938063Q35666289-1C0DF618-E862-4E72-9082-340679C17349Q36003926-7C3AEBF5-571F-4ACA-A635-AEBEB843B3A2Q36413592-2B11B14B-B19B-4EA9-99BD-A49850B77F58Q36473977-DB93453C-3A99-49ED-B299-4CB7346EC938Q37343310-8BFF5727-4AA3-4FF6-AE18-F4C68F74E848Q37397941-9BC68C1B-71B5-4247-992A-0BFB3FE8287FQ37411775-59380CB8-F6BB-4736-B671-EA190695DF2DQ37416750-A4CF703C-D017-4CD5-B830-4262B9B59A40Q37479222-0E1DAC93-B857-4BE0-897B-E6B4F9167051Q37860317-CD49E664-2DF2-492C-82FC-E425E41B7FC3Q37938682-43979115-8E63-42C7-AA52-8192BE3763DAQ39251175-FDF4FEDF-81EA-4DA1-AEA9-75088881AB5DQ39319404-8B102AD5-3F12-487C-BED3-CC815E7520CCQ39762318-57E38451-9D58-4986-AF8E-5FAB59179B74Q39883012-C3B8FA2F-971B-432B-B2C7-B45F921BA754Q41987617-674B8127-A115-4D75-8B2D-1109C089788CQ42044617-D9E9037C-BFC0-48FC-9E1A-41BE3D3565EDQ42414078-9A553879-9355-4186-AACC-E92ED6086FF2Q42575947-B62BF696-5D84-49EE-BF82-CCEB4E1979D3Q47096771-583E47D2-129B-4E6F-AD1F-29B0FE5F8EC7Q47438354-7F199D86-DB8C-4D1E-BD8C-74193F81556DQ47744270-C86BC971-5BA8-4D36-AD3B-23978494D0A6Q51154144-42A133C4-D75F-4655-8691-645ED180AC2C
P2860
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
X11 proteins regulate the tran ...... site-cleaving enzyme in brain.
@en
type
label
X11 proteins regulate the tran ...... site-cleaving enzyme in brain.
@en
prefLabel
X11 proteins regulate the tran ...... site-cleaving enzyme in brain.
@en
P2093
P2860
P356
P1476
X11 proteins regulate the tran ...... site-cleaving enzyme in brain.
@en
P2093
Robert Vassar
Tadashi Nakaya
Toshiharu Suzuki
Yoshitake Sano
Yuhki Saito
P2860
P304
35763-35771
P356
10.1074/JBC.M801353200
P407
P577
2008-10-09T00:00:00Z