Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
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Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγDevelopment of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skinchemalot and chemalot_knime: Command line programs as workflow tools for drug discovery.RORγ antagonists and inverse agonists: a patent review.Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors.Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.Synthetic RORγt Agonists Enhance Protective Immunity.N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists.A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.Optimal affinity ranking for automated virtual screening validated in prospective D3R grand challenges.Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.From RORγt Agonist to Two Types of RORγt Inverse Agonists.
P2860
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P2860
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Minor Structural Change to Ter ...... Opposite Mechanisms of Action.
@en
type
label
Minor Structural Change to Ter ...... Opposite Mechanisms of Action.
@en
prefLabel
Minor Structural Change to Ter ...... Opposite Mechanisms of Action.
@en
P2093
P2860
P356
P1476
Minor Structural Change to Ter ...... Opposite Mechanisms of Action
@en
P2093
Adam R Johnson
Alberto Gobbi
Benjamin P Fauber
Brenda Burton
Christine Everett
Céline Eidenschenk
Gladys de Leon Boenig
Harvey Wong
Heidi A Wallweber
Marya Liimatta
P2860
P304
P356
10.1021/ML500420Y
P577
2014-12-04T00:00:00Z