Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
about
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairBiochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesCharacterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reactionA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damageTargeting DNA topoisomerase II in cancer chemotherapyCollision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' AdductsMolecular mechanisms of etoposideDNA double-strand break repair pathway choice and cancerNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairMechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairThe role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and mythsDNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairRelease of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B virusesSynthetic viability genomic screening defines Sae2 function in DNA repair.DNA end resection--unraveling the tail.Tdp2: a means to fixing the endsAPE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaksRecognition and repair of chemically heterogeneous structures at DNA endsTetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsThe Mre11-Rad50-Xrs2 complex is required for yeast DNA postreplication repairRegulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair.Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics.Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyondBiochemical mechanism of DSB end resection and its regulation.Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Interdependence of the rad50 hook and globular domain functionsTwo separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair
P2860
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P2860
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Distinct requirements for the ...... poisomerase I and II from DNA.
@en
type
label
Distinct requirements for the ...... poisomerase I and II from DNA.
@en
prefLabel
Distinct requirements for the ...... poisomerase I and II from DNA.
@en
P2860
P1433
P1476
Distinct requirements for the ...... poisomerase I and II from DNA.
@en
P2093
Edgar Hartsuiker
Matthew J Neale
P2860
P304
P356
10.1016/J.MOLCEL.2008.11.021
P577
2009-01-01T00:00:00Z