A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753.
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Novel pharmacology: asimadoline, a kappa-opioid agonist, and visceral sensationEfficacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndromeNovel developments with selective, non-peptidic kappa-opioid receptor agonistsDynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic ratsAnti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonistWill peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans.Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesicThe role of kappa-opioid receptor activation in mediating antinociception and addiction.Practical guide to the management of acute and chronic pain in the presence of drug tolerance for the healthcare practitioner.Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome.Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities.Treatment of Functional Dyspepsia.Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review.Preclinical studies of opioids and opioid antagonists on gastrointestinal function.Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment.Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.Kappa opioids and the modulation of pain.Opioid receptor targeting ligands for pain management: a review and update.An update on current pharmacotherapy options for dyspepsia.TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.Emerging drugs for functional dyspepsia.Emerging drug for diarrhea predominant irritable bowel syndrome.Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome.Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug designEndogenous opioid analgesia in peripheral tissues and the clinical implications for pain control.Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug.Opioid mechanisms controlling renal function.Influence of asimadoline, a new kappa-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man.Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain.Asimadoline, a kappa-opioid agonist, and satiation in functional dyspepsia.Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity.Stimulation of peripheral kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway.Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice.Effects of intracolonic opioid receptor agonists on polymodal pelvic nerve afferent fibers in the rat.Involvement of kappa-opioid receptors in visceral nociception in mice.Effects of asimadoline, a kappa-opioid agonist, on satiation and postprandial symptoms in health.Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats.Involvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171.
P2860
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P2860
A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A pharmacological profile of t ...... d receptor agonist, EMD 61753.
@en
type
label
A pharmacological profile of t ...... d receptor agonist, EMD 61753.
@en
prefLabel
A pharmacological profile of t ...... d receptor agonist, EMD 61753.
@en
P2093
P2860
P1476
A pharmacological profile of t ...... d receptor agonist, EMD 61753.
@en
P2093
Bartoszyk GD
Gottschlich R
Greiner HE
P2860
P304
P356
10.1111/J.1476-5381.1994.TB17142.X
P407
P577
1994-12-01T00:00:00Z