Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex.
about
SCYL pseudokinases in neuronal function and survivalCrystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasmCex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p.Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms.Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility.Disruptive SCYL1 Mutations Underlie a Syndrome Characterized by Recurrent Episodes of Liver Failure, Peripheral Neuropathy, Cerebellar Atrophy, and Ataxia.Human mitochondrial tRNA quality control in health and disease: a channelling mechanism?Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications.Plants, like mammals, but unlike Saccharomyces, do not regulate nuclear-cytoplasmic tRNA trafficking in response to nutrient stress.Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p.The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.Schizosaccharomyces pombe, unlike Saccharomyces cerevisiae, may not directly regulate nuclear-cytoplasmic transport of spliced tRNAs in response to nutrient availability.SCYL1 variants cause a syndrome with low γ-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN).
P2860
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P2860
Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Scyl1 facilitates nuclear tRNA ...... g at the nuclear pore complex.
@en
type
label
Scyl1 facilitates nuclear tRNA ...... g at the nuclear pore complex.
@en
prefLabel
Scyl1 facilitates nuclear tRNA ...... g at the nuclear pore complex.
@en
P2860
P356
P1476
Scyl1 facilitates nuclear tRNA ...... g at the nuclear pore complex.
@en
P2093
Dev Mangroo
Shawn C Chafe
P2860
P304
P356
10.1091/MBC.E10-03-0176
P577
2010-05-26T00:00:00Z