Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
about
CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferationFundamentals of cancer metabolismAnticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effectThe mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trialsThe role of the ribosome in the regulation of longevity and lifespan extensionEnergy disruptors: rising stars in anticancer therapy?Oncogenes strike a balance between cellular growth and homeostasisAmino acid management in cancerIntegrating canonical and metabolic signalling programmes in the regulation of T cell responsesmTORC1 signaling activates NRF1 to increase cellular proteasome levelsThe role of tumor suppressor p53 in the antioxidant defense and metabolismThe expanding role of mTOR in cancer cell growth and proliferationNutrient regulation of the mTOR complex 1 signaling pathwayDynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis.Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complexJudicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesAdipose tissue dysfunction and its effects on tumor metabolismmTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingLa-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTORHepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)Where is mTOR and what is it doing there?Lignocellulose depolymerization occurs via an environmentally adapted metabolic cascades in the wood-rotting basidiomycete Phanerochaete chrysosporiumComplementary substrate-selectivity of metabolic adaptive convergence in the lignocellulolytic performance by Dichomitus squalensGenetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysisPhosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.The role of target of rapamycin signaling networks in plant growth and metabolism.From Krebs to clinic: glutamine metabolism to cancer therapy.The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma.Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesisEpidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.Targeting mTOR dependency in pancreatic cancerTargeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translationSestrins orchestrate cellular metabolism to attenuate aging.Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.Activation of diverse signalling pathways by oncogenic PIK3CA mutations.Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.
P2860
Q24298423-3F70C918-BD21-4029-B0B0-B0201E0DD657Q26744062-6C0CFAB9-D433-48E5-97AD-2FFC7F9360B5Q26745461-ABBAE805-CDF5-4029-B60A-9B33788F8C6FQ26751155-40B2587C-D097-410C-B739-1D1F69CFE8F1Q26770848-4B68AE06-5C89-43E2-A0D8-AD6112D611A0Q26771300-3A9574C5-9CE0-4101-B567-22C8FCFE11A6Q26798085-62193944-67C0-4246-B4CE-2AB2E069E68AQ26798087-267D0554-FDC8-4596-90E2-3AF89F1776F5Q26851446-1359F9B5-97C6-4517-AB0C-1419E049AB75Q27012468-21E8E188-385E-4ACB-A6A9-2130431CCDD4Q27027604-D204B01D-590E-4890-8773-D09EAB715792Q27027797-D0C43EAD-C445-48BB-93A8-FDCB577B62B8Q27027823-29E76E0D-05A3-44AB-AFCB-0A27E03F83E6Q27934628-E30597B9-EB6C-4067-84BC-2AEA1677AD4AQ28070171-338CEDA0-452C-4786-A242-D71A2F959A73Q28071388-131291E8-92D7-4D56-B653-D8F545545E6AQ28080748-B5679040-3C65-439F-847F-259323EF55CFQ28081442-93C8B7FC-DA83-41ED-A5FB-1E73FFB33316Q28118644-62F59734-DCF6-4B9C-BB96-74448CA6A40CQ28270006-E0969D86-4092-4A86-B428-26DC524AD3A9Q28299373-4B3E0883-9FD3-45B2-97EF-31D3F9DA507DQ28305068-FD0F2FC7-008A-430E-8092-E78667BF5E44Q28649615-37EA8B64-9DDF-4B17-A276-F3C1387AF997Q28652318-DC5BC306-A4EA-4AE3-BFE0-C4043440239EQ29248629-2C13CF06-1F6B-45A4-B2FD-71F8AB0E2F55Q30396867-CB1D37A7-19A6-4BA2-A689-9705530EEFB5Q33357441-161FD93B-EA98-4114-88C9-494289341557Q33834498-4D7F8858-AE42-49B6-9D83-2C1132D46A5AQ33838601-230A16A5-355E-4DBA-8AAC-0CF531DA4197Q33923074-10F6A98B-5169-4DBF-8059-F3D436935973Q33947130-002A90EC-D0DB-48F4-AFA0-266ED0E8230DQ34044149-B12AB555-502D-4BF9-8CCB-193F5C598029Q34060841-DF2A4B71-84E3-4DE0-A8E3-6F5DEB7964BFQ34092334-43053BC5-8685-4CF5-A4D3-11BE7CBD86CCQ34177843-CB0CE0A1-277B-495D-B3C3-47E338581192Q34308263-E4A92E7E-B53B-48F7-97E6-7C454B611B98Q34372569-FD891147-5D58-4EE0-886A-E82F33F157AFQ34405226-C5D5BABA-167B-4EC3-AF7B-13E5649DAC1AQ34408364-1821B711-583B-4929-9176-07C8933A3AEBQ34417518-A557C9F5-EC03-476C-A92A-AA5F4C92CA0B
P2860
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
@en
type
label
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
@en
prefLabel
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
@en
P2093
P2860
P356
P1433
P1476
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
@en
P2093
Brendan D Manning
Issam Ben-Sahra
Jessica J Howell
John M Asara
P2860
P304
P356
10.1126/SCIENCE.1228792
P407
P577
2013-02-21T00:00:00Z