Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. - Wikidata - awgldk - TriplyDB

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

http://www.wikidata.org/entity/Q41984465

about

Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977 Synthesis of nucleoside phosphate and phosphonate prodrugs Prodrugs of phosphonates and phosphates: crossing the membrane barrier New Antiretroviral Treatment for HIV A cutting-edge view on the current state of antiviral drug development.Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917.In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate.Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2'-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs.Elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide for the treatment of HIV in adults.ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites The role of tenofovir alafenamide in future HIV management.Rilpivirine, emtricitabine and tenofovir alafenamide: single-tablet combination for the treatment of HIV-1 infection in selected patients.Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection.Tenofovir Alafenamide.Emtricitabine + tenofovir alafenamide for the treatment of HIV.Tenofovir alafenamide, emtricitabine, elvitegravir, and cobicistat combination therapy for the treatment of HIV.Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.Tenofovir alafenamide for the treatment of chronic hepatitis B virus infection.Tenofovir Alafenamide: A Review in Chronic Hepatitis B.Long acting systemic HIV pre-exposure prophylaxis: an examination of the field.Effects of a Nutritional Protein-Rich Drink on the Pharmacokinetics of Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Alafenamide, and Tenofovir Compared With a Standard Meal in Healthy Japanese Male Subjects.Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy The ProTides Boom.Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine.Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells.Applying the prodrug strategy to α-phosphonocarboxylate inhibitors of Rab GGTase--synthesis and stability studies.

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P2860

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

http://www.wikidata.org/entity/Q41984465

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.

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type

label

Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.

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Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.

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Antimicrobial Agents and Chemotherapy

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Cathepsin A is the major hydro ...... prodrugs GS-7340 and GS-9131.

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P2093

Craig Gibbs

http://www.w3.org/2001/XMLSchema#string

Holly MacArthur

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Martin McDermott

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Nilima Kutty

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Ruth Wang

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Swami Swaminathan

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Tomas Cihlar

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William Lee

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Xiaohong Liu

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P2860

Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates

Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism

Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity

A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein"

Inactivation of endothelin I by deamidase (lysosomal protective protein)

Human placental neuraminidase. Activation, stabilization and association with beta-galactosidase and its protective protein

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

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543-550

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10.1128/AAC.00968-06

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2

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51

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17145787

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