Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. - Wikidata - awgldk - TriplyDB

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice.

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice.

http://www.wikidata.org/entity/Q41988947

about

Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism Hypoxia-inducible factors as molecular targets for liver diseases The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis Alcoholic liver disease: pathogenesis and new therapeutic targets.Leveraging oxidative stress questions in vivo: Implications and limitations Gut Microbiota and Host Reaction in Liver Diseases Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease.Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice.Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis.Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation.Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α.Pathogenesis of alcoholic liver disease: role of oxidative metabolism.microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis.A novel antioxidant multitarget iron chelator M30 protects hepatocytes against ethanol-induced injury Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism.Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes.Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice.Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes.Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis.Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice New Approaches for Studying Alcoholic Liver Disease Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice.Simulating sleep apnea by exposure to intermittent hypoxia induces inflammation in the lung and liver.Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation.Inflammation in alcoholic liver disease.The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis.Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo Mouse model of chronic and binge ethanol feeding (the NIAAA model)Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant.Chromatin as an oxygen sensor and active player in the hypoxia response.Hypoxia and hypoxia inducible factors: diverse roles in liver diseases.Hypoxia and fatty liver.

P2860

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

P2860

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice.

http://www.wikidata.org/entity/Q41988947

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Hepatocyte-specific hypoxia-in ...... hol-induced steatosis in mice.

@en

type

label

Hepatocyte-specific hypoxia-in ...... hol-induced steatosis in mice.

@en

prefLabel

Hepatocyte-specific hypoxia-in ...... hol-induced steatosis in mice.

@en

P1433

Q41988947-8928D1A9-39D9-4472-872C-4306A0370B55

P1476

Q41988947-7543E1F0-810D-4AEB-B839-9D977A810444

P2093

Q41988947-22D1E877-6025-4310-8214-C1641F7B01EA

Q41988947-6343C0FB-86F3-4ADB-A2F9-29F2FFFB62A6

Q41988947-67B1816E-155B-478E-A7B2-8934A26C2160

Q41988947-7989CB18-B269-4A86-AF98-5AE2220FBFC4

Q41988947-88166E28-590D-4A31-A1D7-BE444419C2E2

Q41988947-988061A0-FFE7-412C-BB8B-C0AF1DC4451B

Q41988947-98FE14C8-ACAA-45A8-A040-F4324E769FA2

Q41988947-C17F7CB7-0838-44A2-B107-AE0B919B3574

P2860

Q41988947-141692C5-D159-4586-BC54-5289F70B39A2

Q41988947-1A70EBFA-4210-496E-A33B-680E5C64BFB9

Q41988947-20719BEE-D227-444A-BC67-88C683501E29

Q41988947-2EB58811-C256-46B4-B590-A9ADB8764451

Q41988947-3CBB8ED3-27B9-4E2F-9348-B359B1196C87

Q41988947-70F26397-28C3-4838-A463-FD223BD70469

Q41988947-766095D6-30DB-4A1F-814A-ED23DE7B08AE

Q41988947-7B17170C-EB4A-4123-B056-5D3C9414A35C

Q41988947-811C6095-0E42-46F4-8B61-A045AB99978F

Q41988947-837950EE-0D6C-4B27-8090-7E626A40FC92

P304

Q41988947-A6635F5C-C45D-40B3-A018-9214F7299D6A

P31

Q41988947-A4D313F7-E6C1-4ECC-9539-F81E13FCBBD2

P356

Q41988947-0947BB7A-C1FA-4BB1-8A68-5DEB0F6EA61C

P407

Q41988947-5EC74953-2055-4562-BC71-E8F66E850488

P433

Q41988947-522F91CE-0320-494D-9C1A-3BDCEFF56A2E

P478

Q41988947-9534C419-6533-44C7-9054-8C16D8BB34FD

P50

Q41988947-06DF3991-8F72-4488-A22D-8B2F2BBA5568

P577

Q41988947-9E81A438-B06C-49A5-8796-CBA7BEEACBF8

P5875

Q41988947-B1028585-5589-400E-9CB3-A51E4DC33CFD

P698

Q41988947-1E8AD1C9-3152-4DE3-982B-C0D69372C3A4

P921

Q41988947-BEDDC37C-1ED6-4C1C-BE05-EB46CC5F6222

P932

Q41988947-AC0500AB-94CE-4E28-9D23-7441193AF2B2

P356

P1433

P1476

Hepatocyte-specific hypoxia-in ...... ohol-induced steatosis in mice

@en

P2093

Bharath Nath

http://www.w3.org/2001/XMLSchema#string

Christian Mueller

http://www.w3.org/2001/XMLSchema#string

Donna Catalano

http://www.w3.org/2001/XMLSchema#string

Gyongyi Szabo

http://www.w3.org/2001/XMLSchema#string

Ivan Levin

http://www.w3.org/2001/XMLSchema#string

Jan Petrasek

http://www.w3.org/2001/XMLSchema#string

Karen Kodys

http://www.w3.org/2001/XMLSchema#string

Timea Csak

http://www.w3.org/2001/XMLSchema#string

P2860

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein.

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity.

Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet.

Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression.

P304

1526-1537

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/HEP.24256

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

53

http://www.w3.org/2001/XMLSchema#string

P50

Pranoti S. Mandrekar

P577

2011-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51077100

http://www.w3.org/2001/XMLSchema#string

P698

21520168

http://www.w3.org/2001/XMLSchema#string

P921

P932

3104403

http://www.w3.org/2001/XMLSchema#string