Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.

about

The discovery and development of romidepsin for the treatment of T-cell lymphoma.Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.

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Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.

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http://www.wikidata.org/entity/Q42009840

description

2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

@zh-sg

2016年學術文章

@yue

2016年學術文章

@zh

2016年學術文章

@zh-hant

name

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@en

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@nl

type

Item

label

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@en

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@nl

prefLabel

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@en

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@nl

P1476

Romidepsin enhances the cytoto ...... bination in malignant T-cells.

@en

P2093

Benigno C Valdez

http://www.w3.org/2001/XMLSchema#string

Borje S Andersson

http://www.w3.org/2001/XMLSchema#string

David Murray

http://www.w3.org/2001/XMLSchema#string

Esmeralda C Teo

http://www.w3.org/2001/XMLSchema#string

Jonathan E Brammer

http://www.w3.org/2001/XMLSchema#string

Richard E Champlin

http://www.w3.org/2001/XMLSchema#string

Yago Nieto

http://www.w3.org/2001/XMLSchema#string

Yan Liu

http://www.w3.org/2001/XMLSchema#string

Yang Li

http://www.w3.org/2001/XMLSchema#string

P2860

Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases

Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data

The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways.

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination.

Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors.

The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival

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100-108

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scholarly article

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10.1016/J.LEUKRES.2016.05.019

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http://www.w3.org/2001/XMLSchema#string

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Chitra Hosing

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2016-05-27T00:00:00Z

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27294334

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4961533

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Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.

about

P2860

P2860

Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.

description

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type

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P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P698

P932