FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination.
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Macrocyclic histone deacetylase inhibitorsImproved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesisNatural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma.Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphomaHistone deacetylase inhibitors from Burkholderia thailandensis.Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968Romidepsin targets multiple survival signaling pathways in malignant T cellsDetermination of the cyclic depsipeptide FK228 in human and mouse plasma by liquid chromatography with mass-spectrometric detection.Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffoldDiscovery and mechanism of natural products as modulators of histone acetylation.Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.α,β-Dehydroamino acids in naturally occurring peptides.Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.Thailandepsin a.Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis.Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.FK228 from Burkholderia thailandensis MSMB43.Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228
P2860
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P2860
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
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1994年の論文
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1994年学术文章
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1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
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name
FR901228, a novel antitumor bi ...... . II. Structure determination.
@ast
FR901228, a novel antitumor bi ...... . II. Structure determination.
@en
FR901228, a novel antitumor bi ...... . II. Structure determination.
@nl
type
label
FR901228, a novel antitumor bi ...... . II. Structure determination.
@ast
FR901228, a novel antitumor bi ...... . II. Structure determination.
@en
FR901228, a novel antitumor bi ...... . II. Structure determination.
@nl
prefLabel
FR901228, a novel antitumor bi ...... . II. Structure determination.
@ast
FR901228, a novel antitumor bi ...... . II. Structure determination.
@en
FR901228, a novel antitumor bi ...... . II. Structure determination.
@nl
P2093
P1476
FR901228, a novel antitumor bi ...... . II. Structure determination.
@en
P2093
P304
P577
1994-03-01T00:00:00Z