Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
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Emerin-prelamin A interplay in human fibroblastsLoss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerinSevere mandibuloacral dysplasia-associated lipodystrophy and progeria in a young girl with a novel homozygous Arg527Cys LMNA mutationMolecular insights into the premature aging disease progeriaPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersRecent advances in understanding the role of lamins in health and diseaseLamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genomeDiscordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS).Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells.NET23/STING promotes chromatin compaction from the nuclear envelopeRapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamicsNuclear lamins: major factors in the structural organization and function of the nucleus and chromatinNuclear lamins and chromatin: when structure meets function.Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient miceRole of ATRX in chromatin structure and function: implications for chromosome instability and human diseaseA lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells.Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria.Nuclear lamins: key regulators of nuclear structure and activitiesBarrier-to-Autointegration Factor influences specific histone modificationsNeonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newbornThe role of lamin B1 for the maintenance of nuclear structure and function.Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment.A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus.A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction.Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.The nuclear lamina. Both a structural framework and a platform for genome organization.Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease.Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Lamin A, farnesylation and agingPrelamin A-mediated nuclear envelope dynamics in normal and laminopathic cells.Nuclear damages and oxidative stress: new perspectives for laminopathies.Hutchinson-Gilford progeria syndrome through the lens of transcription.Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathiesEffects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro.
P2860
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P2860
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@en
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@nl
type
label
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@en
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@nl
prefLabel
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@en
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@nl
P2860
P50
P1476
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
@en
P2093
N M Maraldi
V K Parnaik
P2860
P2888
P304
P356
10.1007/S00018-005-5318-6
P50
P577
2005-11-01T00:00:00Z