Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase.
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Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA GlycosylaseDuplex interrogation by a direct DNA repair protein in search of base damageN-glycosyl bond formation catalyzed by human alkyladenine DNA glycosylaseHopping enables a DNA repair glycosylase to search both strands and bypass a bound protein.Human base excision repair creates a bias toward -1 frameshift mutationsNonspecific DNA binding and coordination of the first two steps of base excision repair.Recent advances in the structural mechanisms of DNA glycosylasesCritical role of DNA intercalation in enzyme-catalyzed nucleotide flippingSubstitution of active site tyrosines with tryptophan alters the free energy for nucleotide flipping by human alkyladenine DNA glycosylase.Kinetic mechanism for the excision of hypoxanthine by Escherichia coli AlkA and evidence for binding to DNA ends.Probing the DNA structural requirements for facilitated diffusion.Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by AlkA.Thermodynamic signature of DNA damage: characterization of DNA with a 5-hydroxy-2'-deoxycytidine·2'-deoxyguanosine base pair.Repair of Alkylation Damage in Eukaryotic Chromatin Depends on Searching Ability of Alkyladenine DNA Glycosylase.Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase.The formation of catalytically competent enzyme-substrate complex is not a bottleneck in lesion excision by human alkyladenine DNA glycosylase.Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication.Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue.
P2860
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P2860
Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@en
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@nl
type
label
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@en
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@nl
prefLabel
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@en
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@nl
P2860
P356
P1433
P1476
Kinetic mechanism for the flip ...... alkyladenine DNA glycosylase.
@en
P2093
Abigail E Wolfe
Patrick J O'Brien
P2860
P304
11357-11369
P356
10.1021/BI9015082
P407
P577
2009-12-01T00:00:00Z