The N terminus of p53 regulates its dissociation from DNA.
about
Modes of p53 regulationp53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA bindingMechanisms of regulatory diversity within the p53 transcriptional network.E2 ligase dRad6 regulates DMP53 turnover in Drosophilatumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes.Analysis of p53 "latency" and "activation" by fluorescence correlation spectroscopy. Evidence for different modes of high affinity DNA binding.Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain.The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominanceThe structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein.Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.Investigating the Influence of Magnesium Ions on p53-DNA Binding Using Atomic Force Microscopy.p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair.The C terminus of p53 binds the N-terminal domain of MDM2.Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets.p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family.Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.
P2860
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P2860
The N terminus of p53 regulates its dissociation from DNA.
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
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2000年论文
@zh-cn
name
The N terminus of p53 regulates its dissociation from DNA.
@en
The N terminus of p53 regulates its dissociation from DNA.
@nl
type
label
The N terminus of p53 regulates its dissociation from DNA.
@en
The N terminus of p53 regulates its dissociation from DNA.
@nl
prefLabel
The N terminus of p53 regulates its dissociation from DNA.
@en
The N terminus of p53 regulates its dissociation from DNA.
@nl
P2093
P2860
P356
P1476
The N terminus of p53 regulates its dissociation from DNA.
@en
P2093
P2860
P304
39944-39953
P356
10.1074/JBC.M002509200
P407
P577
2000-12-01T00:00:00Z