Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.
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Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER networkSpastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretionThe Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic ParaplegiasHereditary spastic paraplegia SPG4: what is known and not known about the disease.Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathwayFunctional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegiaGenetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in Drosophila melanogaster.Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).Drosophila melanogaster in the study of human neurodegeneration.Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity.BMP signaling and microtubule organization regulate synaptic strengthLoss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.Spastin binds to lipid droplets and affects lipid metabolism.Katanin regulates dynamics of microtubules and biogenesis of motile cilia.Aging perturbs 26S proteasome assembly in Drosophila melanogasterAll neuropathies great and small.The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutationsThe genetics of hereditary spastic paraplegia and implications for drug therapy.Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila.Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization.Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.The synaptic cytoskeleton in development and disease.Cellular pathways of hereditary spastic paraplegia.Importance of gene dosage in controlling dendritic arbor formation during development.Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders.Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways.Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors.Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation.Patient-Derived Stem Cell Models in HSP: Disease Modelling and Drug DiscoveryFunctional differences of short and long isoforms of spastin harboring missense mutationHereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives
P2860
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P2860
Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Disease-related phenotypes in ...... by treatment with vinblastine.
@en
Disease-related phenotypes in ...... by treatment with vinblastine.
@nl
type
label
Disease-related phenotypes in ...... by treatment with vinblastine.
@en
Disease-related phenotypes in ...... by treatment with vinblastine.
@nl
prefLabel
Disease-related phenotypes in ...... by treatment with vinblastine.
@en
Disease-related phenotypes in ...... by treatment with vinblastine.
@nl
P2093
P2860
P356
P1476
Disease-related phenotypes in ...... by treatment with vinblastine.
@en
P2093
Elena Sartori
Genny Orso
Maria Giovanna Rossetto
P2860
P304
P356
10.1172/JCI24694
P407
P577
2005-11-01T00:00:00Z