Klotho is a substrate for alpha-, beta- and gamma-secretase - Wikidata - awgldk - TriplyDB

Klotho is a substrate for alpha-, beta- and gamma-secretase

Klotho is a substrate for alpha-, beta- and gamma-secretase

http://www.wikidata.org/entity/Q42078322

about

Klotho in cardiovascular disease: Current and future perspectives Biological Role of Anti-aging Protein Klotho Klotho, stem cells, and aging Receptor tyrosine kinases in the nucleus Klotho and phosphate are modulators of pathologic uremic cardiac remodeling.The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence.ADAM-17: the enzyme that does it all.Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia.α-Klotho protects against oxidative damage in pulmonary epithelia.α-Klotho is an acute phase protein and altered by restraint stress in mice Klotho deficiency causes vascular calcification in chronic kidney disease.The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans.Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody Klotho and the aging process Klotho: its various functions and association with sickle cell disease subphenotypes.Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress.Role of Klotho in aging, phosphate metabolism, and CKD.Molecular basis of Klotho: from gene to function in aging Klotho and kidney disease.Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective Phosphate and Klotho.Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.Renal Production, Uptake, and Handling of Circulating αKlotho Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet Soluble Klotho protein as a novel serum biomarker in patients with acromegaly.αKlotho deficiency in acute kidney injury contributes to lung damage.Systemic Control of Bone Homeostasis by FGF23 Signaling.The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy.The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.Secreted klotho and chronic kidney disease Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice.Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis Klotho has dual protective effects on cisplatin-induced acute kidney injury.

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Klotho is a substrate for alpha-, beta- and gamma-secretase

http://www.wikidata.org/entity/Q42078322

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Klotho is a substrate for alpha-, beta- and gamma-secretase

@en

Klotho is a substrate for alpha-, beta- and gamma-secretase

@nl

type

label

Klotho is a substrate for alpha-, beta- and gamma-secretase

@en

Klotho is a substrate for alpha-, beta- and gamma-secretase

@nl

prefLabel

Klotho is a substrate for alpha-, beta- and gamma-secretase

@en

Klotho is a substrate for alpha-, beta- and gamma-secretase

@nl

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P356

J.FEBSLET.2009.09.009

P1433

P1476

Klotho is a substrate for alpha-, beta- and gamma-secretase

@en

P2093

Christoph Kaether

http://www.w3.org/2001/XMLSchema#string

Daniela Reichenbach

http://www.w3.org/2001/XMLSchema#string

Karina Reiss

http://www.w3.org/2001/XMLSchema#string

Laura Bloch

http://www.w3.org/2001/XMLSchema#string

Makoto Kuro-o

http://www.w3.org/2001/XMLSchema#string

Olga Sineshchekova

http://www.w3.org/2001/XMLSchema#string

Paul Saftig

http://www.w3.org/2001/XMLSchema#string

P2860

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Suppression of aging in mice by the hormone Klotho

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Augmented Wnt signaling in a mammalian model of accelerated aging

Regulation of fibroblast growth factor-23 signaling by klotho

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Regulation of oxidative stress by the anti-aging hormone klotho.

Klotho as a regulator of oxidative stress and senescence.

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19737556

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2757472

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