Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct.
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Gap junctions couple astrocytes and oligodendrocytesHuman oligodendrocytes express Cx31.3: function and interactions with Cx32 mutantsGap junctions in inherited human disorders of the central nervous system.Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 ProteinNf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculatureCx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling.Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice.Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system.Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defectsDifferential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation.Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.The role of gap junction channels during physiologic and pathologic conditions of the human central nervous systemEarly disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica.Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality.How do mutations in GJB1 cause X-linked Charcot-Marie-Tooth disease?Brain connexins in demyelinating diseases: therapeutic potential of glial targetsIntrathecal gene therapy rescues a model of demyelinating peripheral neuropathy.KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction.Molecular mechanisms of inherited demyelinating neuropathies.Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation.X-linked Charcot-Marie-Tooth disease.Exome sequencing identification of a GJB1 missense mutation in a kindred with X-linked spinocerebellar ataxia (SCA-X1).Loss of Coupling Distinguishes GJB1 Mutations Associated with CNS Manifestations of CMT1X from Those Without CNS Manifestations.Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.Intraneural GJB1 gene delivery improves nerve pathology in a model of X-linked Charcot-Marie-Tooth disease.The oligodendroglial precursor cell line Oli-neu represents a cell culture system to examine functional expression of the mouse gap junction gene connexin29 (Cx29).Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model.Functional heterotypic interactions between astrocyte and oligodendrocyte connexins.Remyelination in experimentally demyelinated connexin 32 knockout mice.Severe Convulsions and Dysmyelination in Both Jimpy and Cx32/47 -/- Mice may Associate Astrocytic L-Channel Function with Myelination and Oligodendrocytic Connexins with Internodal Kv Channels.Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter.What's the Function of Connexin 32 in the Peripheral Nervous System?Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges
P2860
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P2860
Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@en
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@nl
type
label
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@en
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@nl
prefLabel
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@en
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@nl
P2093
P2860
P356
P1476
Cx29 and Cx32, two connexins e ...... and are functionally distinct.
@en
P2093
Alan Enriquez
Andreas Gustafsson
Charles K Abrams
David L Paul
Eric Lancaster
Jai-Yoon Sul
Jonathan Lee
Meejin Ahn
Philip G Haydon
Steven S Scherer
P2860
P304
P356
10.1002/JNR.21561
P577
2008-04-01T00:00:00Z