DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
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Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem CellsBlocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndromeModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesLaminopathies and the long strange trip from basic cell biology to therapyWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsRepression of the Antioxidant NRF2 Pathway in Premature AgingTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeTRF2 and lamin A/C interact to facilitate the functional organization of chromosome endsDefective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.Diseases of the nuclear envelope.Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.The posttranslational processing of prelamin A and disease.Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblastsDNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndromeRole of progerin-induced telomere dysfunction in HGPS premature cellular senescence.Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.The role of DNA damage in laminopathy progeroid syndromes."Laminopathies": a wide spectrum of human diseases.Inner nuclear membrane proteins: impact on human disease.Chromatin remodeling, DNA damage repair and aging.Promotion of tumor development in prostate cancer by progerinDNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation.Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatinRole of lamin b1 in chromatin instabilitySulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient miceSignaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cellsAntisense oligonucleotide induction of progerin in human myogenic cells'Relax and Repair' to restrain aging.Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.Mechanisms of immunosenescence: lessons from models of accelerated immune aging.Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria SyndromeOxydative stress alters nuclear shape through lamins dysregulation: a route to senescence.Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.
P2860
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P2860
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
DNA damage responses in proger ...... tive maturation of prelamin A.
@en
DNA damage responses in proger ...... tive maturation of prelamin A.
@nl
type
label
DNA damage responses in proger ...... tive maturation of prelamin A.
@en
DNA damage responses in proger ...... tive maturation of prelamin A.
@nl
prefLabel
DNA damage responses in proger ...... tive maturation of prelamin A.
@en
DNA damage responses in proger ...... tive maturation of prelamin A.
@nl
P2093
P2860
P356
P1476
DNA damage responses in proger ...... tive maturation of prelamin A.
@en
P2093
Antonio Rusinol
Michael Sinensky
Yiyong Liu
Youjie Wang
P2860
P304
P356
10.1242/JCS.03263
P407
P577
2006-10-24T00:00:00Z