The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity.
about
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNAPeptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNAOrigin and evolution of the ribosomeThe transition state for peptide bond formation reveals the ribosome as a water trapLarge facilities and the evolving ribosome, the cellular machine for genetic-code translationDistinct roles for release factor 1 and release factor 2 in translational quality control.Structure and dynamics of a processive Brownian motor: the translating ribosomeMolecular dynamics simulations suggest that RNA three-way junctions can act as flexible RNA structural elements in the ribosomepH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA.The transition state for formation of the peptide bond in the ribosomeThe role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes.The hybrid state of tRNA binding is an authentic translation elongation intermediateInsights into the molecular determinants of EF-G catalyzed translocation.In vitro experimental system for analysis of transcription-translation coupling.Further in vitro exploration fails to support the allosteric three-site model.Exploring the mechanism of protein synthesis with modified substrates and novel intermediate mimics.Two distinct conformations of the conserved RNA-rich decoding center of the small ribosomal subunit are recognized by tRNAs and release factors.Importance of tRNA interactions with 23S rRNA for peptide bond formation on the ribosome: studies with substrate analogs.Kinetic and thermodynamic studies of peptidyltransferase in ribosomes from the extreme thermophile Thermus thermophilus.A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment.Modulating the activity of the peptidyl transferase center of the ribosome.Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.A structural view on the mechanism of the ribosome-catalyzed peptide bond formation.Rapid peptide bond formation on isolated 50S ribosomal subunits.Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids.Visualization of codon-dependent conformational rearrangements during translation termination.Translational roles of the C75 2'OH in an in vitro tRNA transcript at the ribosomal A, P and E sites.A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue.The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC.An unusual mechanism for EF-Tu activation during tmRNA-mediated ribosome rescue.Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1.rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-TuQuality control by the ribosome following peptide bond formationActivities of the peptidyl transferase center of ribosomes lacking protein L27.Two distinct components of release factor function uncovered by nucleophile partitioning analysis.Mechanistic alternatives for peptide bond formation on the ribosome.
P2860
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P2860
The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The interaction between C75 of ...... peptidyl transferase activity.
@en
The interaction between C75 of ...... peptidyl transferase activity.
@nl
type
label
The interaction between C75 of ...... peptidyl transferase activity.
@en
The interaction between C75 of ...... peptidyl transferase activity.
@nl
prefLabel
The interaction between C75 of ...... peptidyl transferase activity.
@en
The interaction between C75 of ...... peptidyl transferase activity.
@nl
P2093
P2860
P356
P1433
P1476
The interaction between C75 of ...... peptidyl transferase activity.
@en
P2093
Divya Sharma
Elaine M Youngman
Julie L Brunelle
Rachel Green
P2860
P356
10.1261/RNA.2256706
P407
P577
2006-01-01T00:00:00Z