Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

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http://www.wikidata.org/entity/Q42107564
Spin Diffusion Editing for Structural Fingerprints of Therapeutic AntibodiesEffects of localized interactions and surface properties on stability of protein-based therapeutics.Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering.Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor.Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding.Engineering of Fc Fragments with Optimized Physicochemical Properties Implying Improvement of Clinical Potentials for Fc-Based Therapeutics.Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy.Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry.Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction.Localized conformational interrogation of antibody and antibody-drug conjugates by site-specific carboxyl group footprinting.Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass SpectrometryModification of the kinetic stability of immunoglobulin G by solvent additives
P2860

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.

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http://www.wikidata.org/entity/Q42107564
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2015 nî lūn-bûn
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Correlations between changes i ...... for extended serum half-life.
@en
Correlations between changes i ...... for extended serum half-life.
@nl
type
label
Correlations between changes i ...... for extended serum half-life.
@en
Correlations between changes i ...... for extended serum half-life.
@nl
prefLabel
Correlations between changes i ...... for extended serum half-life.
@en
Correlations between changes i ...... for extended serum half-life.
@nl
P1433
P1476
P2093
P2860
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P356
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P5875
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Correlations between changes i ...... for extended serum half-life.
@en
P2093
P2860
P304
P31
P356
10.4161/19420862.2014.985494
P433
P478
P50
P577
P5875
P698
P932