Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
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The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a reviewAnti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targetsInhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468.Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activityInhibition of phosphodiesterase 5 reduces bone mass by suppression of canonical Wnt signaling.Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemopreventionPhosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivoThe cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinomaA novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activityNovel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletionβ-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKGSulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentNew NSAID targets and derivatives for colorectal cancer chemoprevention.COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs.NSAIDs inhibit tumorigenesis, but how?Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs.The effect of pentoxifylline on L-1 sarcoma tumor growth and angiogenesis in Balb/c mice.Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression.Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis.Validation of PDE5 as a Chemoprevention Target.Phosphodiesterase type 5 and cancers: progress and challenges.PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling.
P2860
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P2860
Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@en
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@nl
type
label
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@en
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@nl
prefLabel
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@en
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@nl
P2093
P2860
P1476
Colon tumor cell growth-inhibi ...... hosphodiesterase 5 inhibition.
@en
P2093
Adam B Keeton
Bernard D Gary
Gary A Piazza
Heather N Tinsley
Jose Thaiparambil
Yulia Y Maxuitenko
P2860
P304
P356
10.1158/1940-6207.CAPR-10-0030
P577
2010-09-28T00:00:00Z