The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation - Wikidata - awgldk - TriplyDB

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

http://www.wikidata.org/entity/Q42143163

about

Variant base excision repair proteins: contributors to genomic instability Base excision repair and cancer Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues Human DNA Polymerase Mutations Allowing Efficient Abasic Site Bypass Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase β Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway The E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide Selection Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position Structure and mechanism of DNA polymerase β MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles Base excision repair A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation.Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.DNA repair and personalized breast cancer therapy Substrate-induced DNA polymerase β activation."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Involvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene.Variation in base excision repair capacity.The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation Metal-induced DNA translocation leads to DNA polymerase conformational activation.Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.Substrate-dependent millisecond domain motions in DNA polymerase β.Human POLB gene is mutated in high percentage of colorectal tumors.Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient.Deregulated expression of DNA polymerase β is involved in the progression of genomic instability Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation.Evidence for base excision repair processing of DNA interstrand crosslinks.The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.

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P2860

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

http://www.wikidata.org/entity/Q42143163

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

The E295K DNA polymerase beta ...... nduces cellular transformation

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The E295K DNA polymerase beta ...... nduces cellular transformation

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type

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The E295K DNA polymerase beta ...... nduces cellular transformation

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The E295K DNA polymerase beta ...... nduces cellular transformation

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The E295K DNA polymerase beta ...... nduces cellular transformation

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The E295K DNA polymerase beta ...... nduces cellular transformation

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Molecular and Cellular Biology

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The E295K DNA polymerase beta ...... nduces cellular transformation

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P2093

Anna Chikova

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Daniel DiMaio

http://www.w3.org/2001/XMLSchema#string

Joann B Sweasy

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Shibani Dalal

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Tieming Lang

http://www.w3.org/2001/XMLSchema#string

P2860

Instability and decay of the primary structure of DNA

A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

AP endonuclease-independent DNA base excision repair in human cells

Is there a link between DNA polymerase beta and cancer?

Completion of base excision repair by mammalian DNA ligases

Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair

Initiation of base excision repair: glycosylase mechanisms and structures.

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.

Repair and genetic consequences of endogenous DNA base damage in mammalian cells.

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5587-5596

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10.1128/MCB.01883-06

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15

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27

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2007-05-25T00:00:00Z

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