Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
about
Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cellsModulating splicing with small molecular inhibitors of the spliceosomeDefects in spliceosomal machinery: a new pathway of leukaemogenesisAlternative splicing for diseases, cancers, drugs, and databasessmFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand bindingThe Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates SplicingNew connections between splicing and human diseasePhosphorylation-mediated regulation of alternative splicing in cancerThe genetics of uveal melanoma: current insightsMicrobial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer TreatmentDefective control of pre-messenger RNA splicing in human diseaseThe role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progressionExome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemiaStructural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density mapsImpact of base pair identity 5' to the spliceosomal branch site adenosine on branch site conformationMutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractorinessIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.Mechanisms of genome instability induced by RNA-processing defects.A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complexComparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.Targeting Splicing in the Treatment of Myelodysplastic Syndromes and Other Myeloid Neoplasms.Incorporating evolutionary information and functional domains for identifying RNA splicing factors in humans.SF3B1 and other novel cancer genes in chronic lymphocytic leukemiaPsoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.Rearrangements within human spliceosomes captured after exon ligation.Kinetic competition during the transcription cycle results in stochastic RNA processing.Intron definition and a branch site adenosine at nt 385 control RNA splicing of HPV16 E6*I and E7 expressionPre-mRNA splicing is a determinant of nucleosome organizationThe anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.The genomic landscape of chronic lymphocytic leukemia: clinical implications.Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing.Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cellsU2 snRNP is required for expression of the 3' end of genes.Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.Identification of small molecule inhibitors of pre-mRNA splicing.Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicingRegulation of toll-like receptor signaling by the SF3a mRNA splicing complex.Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells
P2860
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P2860
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@en
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@nl
type
label
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@en
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@nl
prefLabel
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@en
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@nl
P2860
P356
P1433
P1476
Reduced fidelity of branch poi ...... nti-tumor drug spliceostatin A
@en
P2093
Anna Corrionero
Belén Miñana
P2860
P304
P356
10.1101/GAD.2014311
P577
2011-03-01T00:00:00Z