A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
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Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisDynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Complexins: small but capableDistinct initial SNARE configurations underlying the diversity of exocytosisRole of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexThe importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensorPtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthPhosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridgingThe calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding.Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion.Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex.Re-examining how complexin inhibits neurotransmitter release.A fast, single-vesicle fusion assay mimics physiological SNARE requirements.Single-molecule studies of the neuronal SNARE fusion machinery.Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complexSynaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.Protein determinants of SNARE-mediated lipid mixing.Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex.Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivoThe SNARE complex in neuronal and sensory cells.Tag team action at the synapse.Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formationBinding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycleSequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells.GPCR mediated regulation of synaptic transmission.Enlightening molecular mechanisms through study of protein interactionsSynaptic proteins promote calcium-triggered fast transition from point contact to full fusion.Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.Synaptic vesicle fusion.The SNAP-25 linker as an adaptation toward fast exocytosis.Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release.The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.
P2860
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P2860
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@en
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@nl
type
label
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@en
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@nl
prefLabel
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@en
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@nl
P2093
P2860
P1476
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release.
@en
P2093
P2860
P304
P356
10.1016/J.JMB.2007.01.040
P407
P50
P577
2007-01-23T00:00:00Z