about
Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during developmentIdentification and characterization of a novel serine-threonine kinase gene from the Xp22 regionA novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest originOpitz G/BBB syndrome in Xp22: mutations in the MID1 gene cluster in the carboxy-terminal domain.Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationUncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivoProliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.Therapeutic benefit of lentiviral-mediated neonatal intracerebral gene therapy in a mouse model of globoid cell leukodystrophyLentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.Lentiviral vector integration profiles differ in rodent postmitotic tissuesLentiviral vector-based insertional mutagenesis identifies genes involved in the resistance to targeted anticancer therapies.adLIMS: a customized open source software that allows bridging clinical and basic molecular research studiesWhole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantationTargeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapyLow therapeutic threshold for hepatocyte replacement in murine phenylketonuria.Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapyImmunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.Relevance of an academic GMP Pan-European vector infra-structure (PEVI).Preclinical testing of the safety and tolerability of LV-mediated above normal alpha-L-iduronidase expression in murine and human hematopoietic cells using toxicology and biodistribution GLP studies.In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.Wiskott-Aldrich syndrome protein deficiency in natural killer and dendritic cells affects antitumor immunity.Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.AAV serotype 2 vectors preferentially integrate into active genes in mice.Safe and Efficient Gene Therapy for Pyruvate Kinase DeficiencyShedding of clinical-grade lentiviral vectors is not detected in a gene therapy setting.The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.Targeted genome editing in human repopulating haematopoietic stem cellsVISPA: a computational pipeline for the identification and analysis of genomic vector integration sites.Liver-directed lentiviral gene therapy in a dog model of hemophilia B.Chromosomal integration of adenoviral vector DNA in vivo.Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Eugenio Montini
@ast
Eugenio Montini
@en
Eugenio Montini
@es
Eugenio Montini
@nl
Eugenio Montini
@sl
type
label
Eugenio Montini
@ast
Eugenio Montini
@en
Eugenio Montini
@es
Eugenio Montini
@nl
Eugenio Montini
@sl
prefLabel
Eugenio Montini
@ast
Eugenio Montini
@en
Eugenio Montini
@es
Eugenio Montini
@nl
Eugenio Montini
@sl
P1053
L-1152-2016
P106
P1153
7003421057
P21
P31
P3829
P496
0000-0003-1771-6067