about
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin lociPax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistanceControl of B cell development by Ras-mediated activation of Raf.Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogensEbf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivoAdaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T CellsInterleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.In vivo survival and homeostatic proliferation of natural killer cells.Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infectionBLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.The role of STAT5 in the development, function, and transformation of B and T lymphocytes.Interleukin-2 and STAT5 in regulatory T cell development and functionB cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemiaCoumermycin-induced dimerization of GyrB-containing fusion proteins.Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor.Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis.Membrane localization of Raf assists engagement of downstream effectors.IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.Evidence for heterogeneity of the DPA and DPB alleles derived from a DRw11,DQw7,DPw4 cell line.Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.STAT5 activation underlies IL7 receptor-dependent B cell development.Signal transduction pathways regulating the development of alpha beta T cells.Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Michael A Farrar
@ast
Michael A Farrar
@en
Michael A Farrar
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Michael A Farrar
@nl
Michael A Farrar
@sl
type
label
Michael A Farrar
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Michael A Farrar
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Michael A Farrar
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Michael A Farrar
@nl
Michael A Farrar
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altLabel
Farrar MA
@en
prefLabel
Michael A Farrar
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Michael A Farrar
@en
Michael A Farrar
@es
Michael A Farrar
@nl
Michael A Farrar
@sl
P106
P21
P31
P496
0000-0002-5569-0366