Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. - Wikidata - awgldk - TriplyDB

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

http://www.wikidata.org/entity/Q42188322

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Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface Receptor tyrosine kinases in the nucleus Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems Inhibition of tyrosine kinase receptor Tie2 reverts HCV-induced hepatic stellate cell activation VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation Tie1 controls angiopoietin function in vascular remodeling and inflammation.Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells.Tie2 in tumor endothelial signaling and survival: implications for antiangiogenic therapy.The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors.Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.Molecular imaging in cancer treatment.Molecular control of angiopoietin signalling.Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner Morpholino-Mediated Isoform Modulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) Reduces Colon Cancer Xenograft Growth.Tie1 is required for lymphatic valve and collecting vessel development.Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.Tie1 deficiency induces endothelial-mesenchymal transition.Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.Molecular and cellular mechanisms of ectodomain shedding SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.gamma-Secretase: a multifaceted regulator of angiogenesis Trafficking of receptor tyrosine kinases to the nucleus Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?The vasculature in rheumatoid arthritis: cause or consequence?The many substrates of presenilin/γ-secretase.The physiology of the β-amyloid precursor protein intracellular domain AICD.Life is a pattern: vascular assembly within the embryo.Role of Tie1 in shear stress and atherosclerosis.Tie-1: A potential target for anti-angiogenesis therapy.Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.Effects of CASP5 gene overexpression on angiogenesis of HMEC-1 cells.Shedding-generated Met receptor fragments can be routed to either the proteasomal or the lysosomal degradation pathway.Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis.Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1.Angiogenic Potential and Secretome of Human Apical Papilla Mesenchymal Stem Cells in Various Stress Microenvironments.

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Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

http://www.wikidata.org/entity/Q42188322

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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type

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2.

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Regulated proteolytic processi ...... receptor-tyrosine kinase Tie2

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Gou Young Koh

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Hak-Zoo Kim

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Harprit Singh

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Jais Kavumkal

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Marie B Marron

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P2860

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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30509-30517

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42

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282

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Nicholas Brindle

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6112653

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17728252

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