The physiology of the β-amyloid precursor protein intracellular domain AICD.
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The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?APP intracellular domain-WAVE1 pathway reduces amyloid-β production.Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering apoptosis in U251 glioma cellsMolecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis.Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.APP as a Protective Factor in Acute Neuronal Insults.Turnover of amyloid precursor protein family members determines their nuclear signaling capabilityEpigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexNuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.The keystone of Alzheimer pathogenesis might be sought in Aβ physiologyAltered Innate Immune and Glial Cell Responses to Inflammatory Stimuli in Amyloid Precursor Protein Knockout Mice.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged ratsTRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseModulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.APP Receptor? To Be or Not To Be.Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 MiceER-stress in Alzheimer's disease: turning the scale?Immununochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.Pharmacological targeting of the β-amyloid precursor protein intracellular domain.
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P2860
The physiology of the β-amyloid precursor protein intracellular domain AICD.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@en
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@nl
type
label
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@en
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@nl
prefLabel
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@en
The physiology of the β-amyloid precursor protein intracellular domain AICD.
@nl
P2860
P1476
The physiology of the β-amyloid precursor protein intracellular domain AICD
@en
P2093
Raphaëlle Pardossi-Piquard
P2860
P304
P356
10.1111/J.1471-4159.2011.07475.X
P407
P478
120 Suppl 1
P577
2011-11-28T00:00:00Z