Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. - Wikidata - awgldk - TriplyDB

Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.

Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.

http://www.wikidata.org/entity/Q42194066

about

Pathophysiology of thrombotic thrombocytopenic purpura The molecular biology of thrombotic microangiopathy The unfolded von Willebrand factor response in bloodstream: the self-association perspective Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1 The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.Insights into von Willebrand factor proteolysis: clinical implications.ADAMTS13 and microvascular thrombosis Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency The kidney in thrombotic thrombocytopenic purpura.von Willebrand factor: more than a regulator of hemostasis and thrombosis.Presence of anti-ADAMTS13 antibodies in obesity.VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP.Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13 Is ABO blood group truly a risk factor for thrombosis and adverse outcomes?Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice The thrombospondins.Critical review of mouse models of venous thrombosis.Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.Vascular response to intra-arterial injury in the thrombospondin-1 null mouse Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.Thrombospondin-1: a physiological regulator of nitric oxide signaling Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation Extracellular control of VWF multimer size and thiol-disulfide exchange.Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis.The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche.Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review.Endothelium--role in regulation of coagulation and inflammation.The effects of arterial flow on platelet activation, thrombus growth, and stabilization.Thrombospondins: old players, new games Of von Willebrand factor and platelets.Role of fluid shear stress in regulating VWF structure, function and related blood disorders.Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.

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Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.

http://www.wikidata.org/entity/Q42194066

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Thrombospondin-1 controls vasc ...... VWF from cleavage by ADAMTS13.

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Thrombospondin-1 controls vasc ...... dherence in mice by protecting

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type

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Thrombospondin-1 controls vasc ...... VWF from cleavage by ADAMTS13.

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Thrombospondin-1 controls vasc ...... dherence in mice by protecting

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Thrombospondin-1 controls vasc ...... VWF from cleavage by ADAMTS13.

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Thrombospondin-1 controls vasc ...... VWF from cleavage by ADAMTS13

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Arnaud Bonnefoy

http://www.w3.org/2001/XMLSchema#string

Jack Lawler

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Jos Vermylen

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Kim Daenens

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Marc F Hoylaerts

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Petra Vandervoort

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Rita De Vos

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P2860

ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor

Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics

Cleavage of von Willebrand factor by ADAMTS-13 on endothelial cells

Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3

Cleavage of ultra-large von Willebrand factor by ADAMTS-13 under flow conditions

Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin

Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

Plasma fibronectin promotes thrombus growth and stability in injured arterioles.

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Hendrik B. Feys

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