Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.
about
Metabolic profiling for the identification of Huntington biomarkers by on-line solid-phase extraction capillary electrophoresis mass spectrometry combined with advanced data analysis tools.Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's diseaseA small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease miceA role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's diseaseDARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neuronsThe p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's DiseaseIntegral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction.Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.p75NTR in Huntington's disease: beyond the basal ganglia.Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.Changes in Dopamine Signalling Do Not Underlie Aberrant Hippocampal Plasticity in a Mouse Model of Huntington's Disease.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model.Reduced amygdala volumes are related to motor and cognitive signs in Huntington's disease: The IMAGE-HD study.The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington's disease models
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P2860
Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
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2014年學術文章
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name
Neurotrophin receptor p75(NTR) ...... naptic and memory dysfunction.
@en
type
label
Neurotrophin receptor p75(NTR) ...... naptic and memory dysfunction.
@en
prefLabel
Neurotrophin receptor p75(NTR) ...... naptic and memory dysfunction.
@en
P2093
P2860
P50
P356
P1476
Neurotrophin receptor p75(NTR) ...... naptic and memory dysfunction.
@en
P2093
Alfonsa Zamora-Moratalla
Lilian Enriquez-Barreto
Mar Puigdellívol
Sílvia Ginés
P2860
P304
P356
10.1172/JCI74809
P407
P50
P577
2014-09-02T00:00:00Z