Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

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http://www.wikidata.org/entity/Q42196591
Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damageFlipping the switch from g1 to s phase with e3 ubiquitin ligasesThymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication.Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin.Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.Mismatch repair regulates Cdt1 after UV damage.
P2860

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

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http://www.wikidata.org/entity/Q42196591
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Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
type
label
Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
prefLabel
Two different replication fact ...... and following UV irradiation.
@en
Two different replication fact ...... and following UV irradiation.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Two different replication fact ...... e and following UV irradiation
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932