about
Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells.Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase.Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1Imaging analysis of cell cycle-dependent degradation of Cdt1 in mammalian cellsA DNA-binding domain in the C-terminal region of Cdt2 enhances the DNA synthesis-coupled CRL4Cdt2 ubiquitin ligase activity for Cdt1
P50
Q36302154-12FEBD58-10D6-4EEF-840E-605870A1AD68Q38987472-9EB0D224-79C5-4518-A960-669104AD7D1AQ39259207-998B02EA-66D1-4014-B2E7-84BAA3909AB0Q42196591-D9A2CE14-0D46-40D6-BD5B-9348471FFCA0Q48504668-19784EF6-31F9-4A0E-B1F8-223D88BA65CAQ60924153-BCB7C9C0-5C89-435A-A109-68B8C2A04D72Q88033694-258B37A3-64D3-4EEB-8F6F-C23099925F24Q91072339-AA4408B4-C0ED-490E-B7AB-59DD12DB881E
P50
description
researcher ORCID ID = 0000-0003-1900-4282
@en
wetenschapper
@nl
name
Akiyo Hayashi
@ast
Akiyo Hayashi
@en
Akiyo Hayashi
@es
Akiyo Hayashi
@nl
type
label
Akiyo Hayashi
@ast
Akiyo Hayashi
@en
Akiyo Hayashi
@es
Akiyo Hayashi
@nl
prefLabel
Akiyo Hayashi
@ast
Akiyo Hayashi
@en
Akiyo Hayashi
@es
Akiyo Hayashi
@nl
P31
P496
0000-0003-1900-4282