Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.
about
Development of the mammalian lymphatic vasculaturePlatelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapiesNew horizon in platelet function: with special reference to a recently-found molecule, CLEC-2Proteasome function is required for platelet productionPodoplanin: emerging functions in development, the immune system, and cancerLymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk.Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity.CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMPThrombocytes Correlate with Lymphangiogenesis in Human Esophageal Cancer and Mediate Growth of Lymphatic Endothelial Cells In VitroDistinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.Understanding lymphangiogenesis in knockout models, the cornea, and ocular diseases for the development of therapeutic interventions.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.The snake venom rhodocytin from Calloselasma rhodostoma- a clinically important toxin and a useful experimental tool for studies of C-type lectin-like receptor 2 (CLEC-2)Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.The functional role of platelets in the regulation of angiogenesis.The role of BMPs in endothelial cell function and dysfunction.Molecular and cellular mechanisms of lymphatic vascular maturation.Glycobiology of platelet-endothelial cell interactions.Hypercoagulation in colorectal cancer: what can platelet indices tell us?Emerging roles of podoplanin in vascular development and homeostasis.Platelet-activating factor podoplanin: from discovery to drug developmentModulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin.Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.Building the drains: the lymphatic vasculature in health and disease.Lymphatic vessel development: fluid flow and valve-forming cells.C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice.Platelets as autonomous drones for hemostatic and immune surveillance.Platelet interaction with lymphatics aggravates intestinal inflammation by suppressing lymphangiogenesis.Emerging Roles for Platelets in Inflammation and Disease.Apolipoprotein A-I Modulates Atherosclerosis Through Lymphatic Vessel-Dependent Mechanisms in Mice.Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.Current status of blood 'pharming': megakaryoctye transfusions as a source of platelets.Measurement of soluble C-type lectin-like receptor 2 in human plasma.The platelet-activating receptor C-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice.
P2860
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P2860
Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Platelet activation receptor C ...... f lymphatic endothelial cells.
@en
Platelet activation receptor C ...... f lymphatic endothelial cells.
@nl
type
label
Platelet activation receptor C ...... f lymphatic endothelial cells.
@en
Platelet activation receptor C ...... f lymphatic endothelial cells.
@nl
prefLabel
Platelet activation receptor C ...... f lymphatic endothelial cells.
@en
Platelet activation receptor C ...... f lymphatic endothelial cells.
@nl
P2093
P2860
P356
P1476
Platelet activation receptor C ...... f lymphatic endothelial cells.
@en
P2093
Hideki Fujii
Hirotake Ichise
Katsue Suzuki-Inoue
Katsuhiro Takano
Kazuyoshi Hirayama
Makoto Osada
Masanori Hirashima
Osamu Inoue
Toshiaki Shirai
P2860
P304
22241-22252
P356
10.1074/JBC.M111.329987
P407
P577
2012-05-03T00:00:00Z