Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. - Wikidata - awgldk - TriplyDB

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

http://www.wikidata.org/entity/Q42779021

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Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.Lymph flow regulates collecting lymphatic vessel maturation in vivo.Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies Targets for Ibrutinib Beyond B Cell Malignancies The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.RASA3 is a critical inhibitor of RAP1-dependent platelet activation Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia The role of RNA interference in the developmental separation of blood and lymphatic vasculature Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity.Mucin-type O-glycosylation is critical for vascular integrity.Primary and secondary lymphatic valve development: molecular, functional and mechanical insights.Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets.Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.GATA2 is required for lymphatic vessel valve development and maintenance.Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves Extracellular vesicles are present in mouse lymph and their level differs in atherosclerosis Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Molecular and cellular mechanisms of lymphatic vascular maturation.Glycobiology of platelet-endothelial cell interactions.VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels.Divergence of Vascular Specification in Visceral Lymphoid Organs-Genetic Determinants and Differentiation Checkpoints.Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels.Emerging roles of podoplanin in vascular development and homeostasis.Platelet-activating factor podoplanin: from discovery to drug development Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin.Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.The lymphatic vasculature: development and role in shaping immunity.Lymphatic pumping: mechanics, mechanisms and malfunction.Model systems for platelet receptor shedding.

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P2860

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

http://www.wikidata.org/entity/Q42779021

description

2014 nî lūn-bûn

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2014年の論文

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2014年论文

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Platelets mediate lymphovenous ...... ic separation throughout life.

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Platelets mediate lymphovenous ...... ic separation throughout life.

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Platelets mediate lymphovenous ...... ic separation throughout life.

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Journal of Clinical Investigation

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Platelets mediate lymphovenous ...... tic separation throughout life

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P2093

Bernhard Nieswandt

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Brett Herzog

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Daniel T Sweet

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David R Rawnsley

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Guillermo Oliver

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Lijun Xia

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Mark L Kahn

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MinMin Lu

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Paul R Hess

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Taija Makinen

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P2860

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

Prox1 function is crucial for mouse lens-fibre elongation

Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis

Syk tyrosine kinase required for mouse viability and B-cell development

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

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273-284

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10.1172/JCI70422

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1

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124

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259110360

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24292710

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3871239

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