The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
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Control of androgen biosynthesis in the human through the interaction of Arg347 and Arg358 of CYP17 with cytochrome b5The molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersBiodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.Structures of human steroidogenic cytochrome P450 17A1 with substratesCYP17 inhibitors for prostate cancer therapyRegulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.Moonlighting cytochrome P450 monooxygenases.The implication of neuroactive steroids in Tourette's syndrome pathogenesis: A role for 5α-reductase?Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthood.The steroid metabolome of adrenarcheAndrogenic potential of human fetal adrenals at the end of the first trimester.Intra-adrenal regulation of androgen synthesis.Adrenarche - physiology, biochemistry and human disease.Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer.Recent Structural Insights into Cytochrome P450 Function.Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production.The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5).Xenopus laevis CYP17 regulates androgen biosynthesis independent of the cofactor cytochrome b5.Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women.Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.Cytochromes P450--a family of proteins and scientists-understanding their relationships.Unusual properties of the cytochrome P450 superfamily.The Metabolism, Analysis, and Targeting of Steroid Hormones in Breast and Prostate Cancer.Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque modelSubstrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.Cytochromes p450: roles in diseasesPhosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis.Nonhuman primates as models for human adrenal androgen production: function and dysfunction.The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques.Active site proton delivery and the lyase activity of human CYP17A1.Structural diversity of cytochrome P450 enzyme system.The interplay between bioactive sphingolipids and steroid hormones.Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer.An analysis of the role of active site protic residues of cytochrome P-450s: mechanistic and mutational studies on 17alpha-hydroxylase-17,20-lyase (P-45017alpha also CYP17).CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding.Regioselective hydroxylation of steroid hormones by human cytochromes P450.Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.
P2860
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P2860
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@en
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@nl
type
label
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@en
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@nl
prefLabel
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@en
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@nl
P2093
P356
P1476
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.
@en
P2093
M Katagiri
M R Waterman
P304
P356
10.1006/ABBI.1995.1173
P407
P577
1995-03-01T00:00:00Z