about
The Mdm2 oncoprotein interacts with the cell fate regulator NumbAKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.T cell survival and function requires the c-Abl tyrosine kinaseE6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.Editorial: Human Tumor-Derived p53 Mutants: A Growing Family of OncoproteinsMDM4 is a key therapeutic target in cutaneous melanoma.Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulationMDM4 is a rational target for treating breast cancers with mutant p53.The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein.Increasing intracellular bioavailable copper selectively targets prostate cancer cells.c-Abl phosphorylates Hdmx and regulates its interaction with p53.Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer.Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosisRole of p53 in the progression of gastric cancerHPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling.Stimulating p53 down-under: a report from the 1st Australian p53 Workshop.Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.Moloney virus induction of T-cell lymphomas in a plasmacytomagenic strain of E mu-v-abl transgenic mice.Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33(ING1) in T.Tn human esophageal carcinoma cells.The Transcriptional Landscape of Radiation-Treated Human Prostate Cancer: Analysis of a Prospective Tissue Cohort.Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.Mutant p53 subverts PLK2 function in a novel, reinforced loop of corruption.An Analysis of a Multiple Biomarker Panel to Better Predict Prostate Cancer Metastasis After Radical ProstatectomyBiodosimetric transcriptional and proteomic changes are conserved in irradiated human tissueExploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometryHhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in miceHPV16 E6 augments Wnt signaling in an E6AP-dependent mannerA Role for the Polyproline Domain of p53 in Its Regulation by Mdm2c-Jun and p53 Activity Is Modulated by SUMO-1 ModificationFlow Cytometric Analysis of p53-Induced ApoptosisTP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival
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wetenschapper
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հետազոտող
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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Ygal Haupt
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P108
P106
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P1153
7003537199
P31
P496
0000-0001-5925-0096