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Expression, Purification, and Characterisation of Dehydroquinate Synthase from Pyrococcus furiosusPotent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based designCloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidisReversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthaseSynergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosisTyrosine Latching of a Regulatory Gate Affords Allosteric Control of Aromatic Amino Acid BiosynthesisTargeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthaseAn extended β7α7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthaseEngineering allosteric control to an unregulated enzyme by transfer of a regulatory domainDynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allosteryRemoval of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate bindingNeisseria meningitidisexpresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanineThree sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosisThe substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibitionArg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidisExamining the role of intersubunit contacts in catalysis by 3-deoxy-d-manno-octulosonate 8-phosphate synthaseBiochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensisChange in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed ratesDestabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activityAlternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosisStructural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site waterStructures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active SiteCalculated pKa Variations Expose Dynamic Allosteric Communication NetworksA symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivoryThe structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymesDeletion and gene expression analyses define the paxilline biosynthetic gene cluster in Penicillium paxilli.Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases.The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino AcidsFirst structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramerThe genetic basis for indole-diterpene chemical diversity in filamentous fungi.Using a combination of computational and experimental techniques to understand the molecular basis for protein allostery.Key targets and relevant inhibitors for the drug discovery of tuberculosis.Allosteric ACTion: the varied ACT domains regulating enzymes of amino-acid metabolism.Interdomain Conformational Changes Provide Allosteric Regulation En Route To ChorismateQuaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis.Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.Campylobacter jejuni adenosine triphosphate phosphoribosyltransferase is an active hexamer that is allosterically controlled by the twisting of a regulatory tail.Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pyloriCrystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.
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P50
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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Emily J. Parker
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0000-0002-9571-9987