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Neutron reflectometry studies define prion protein N-terminal peptide membrane bindingThe Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection ResponsesPrion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion diseaseCytosolic caspases mediate mislocalised SOD2 depletion in an in vitro model of chronic prion infection.Copper, endoproteolytic processing of the prion protein and cell signalling.MEK1 transduces the prion protein N2 fragment antioxidant effects.Endoproteolytic cleavage as a molecular switch regulating and diversifying prion protein function.PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.Copper-dependent co-internalization of the prion protein and glypican-1.The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro.Cavitation during the protein misfolding cyclic amplification (PMCA) method--The trigger for de novo prion generation?Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain.Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.Optical imaging detects apoptosis in the brain and peripheral organs of prion-infected mice.Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling.Regulation of prion protein expression by noncoding regions of the Prnp gene.Simplified Murine 3D Neuronal Cultures for Investigating Neuronal Activity and Neurodegeneration.A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding.Investigation of PrPC metabolism and function in live cells : methods for studying individual cells and cell populations.Blood vessel cell death during prion disease: implications for disease management and infection control.Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expressionPrion protein reduces both oxidative and non-oxidative copper toxicitySporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neuronsUsing our mini-brains: cerebral organoids as an improved cellular model for human prion diseasePrion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells
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description
hulumtuese
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researcher
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հետազոտող
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name
Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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prefLabel
Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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Cathryn L. Haigh
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P106
P1153
8881712100
P21
P31
P496
0000-0001-7591-1149