Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.
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Mechanisms of islet amyloidosis toxicity in type 2 diabetesReg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant OutcomeActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.Current status of islet cell replacement and regeneration therapy.Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin.Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20TNF-α acutely upregulates amylin expression in murine pancreatic beta cells.Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids.The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.Residue-specific, real-time characterization of lag-phase species and fibril growth during amyloid formation: a combined fluorescence and IR study of p-cyanophenylalanine analogs of islet amyloid polypeptideStructural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant modelIslet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced ToxicityLocalized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.Inhibition of glycosaminoglycan-mediated amyloid formation by islet amyloid polypeptide and proIAPP processing intermediates.Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide.Implications of peptide assemblies in amyloid diseases.The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation.The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors.Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells.Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide.Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition.Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.Anakinra Protects Against Serum Deprivation-Induced Inflammation and Functional Derangement in Islets Isolated From Nonhuman Primates.Analysis of the role of the conserved disulfide in amyloid formation by human IAPP in homogenous and heterogeneous environments.Extensive Loss of Islet Mass Beyond the First Day After Intraportal Human Islet Transplantation in a Mouse Model.The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.Evolutionary Adaptation and Amyloid Formation: Does the Reduced Amyloidogenicity and Cytotoxicity of Ursine Amylin Contribute to the Metabolic Adaption of Bears and Polar Bears?
P2860
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P2860
Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@en
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@nl
type
label
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@en
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@nl
prefLabel
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@en
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@nl
P2093
P2860
P1433
P1476
Amyloid formation results in r ...... IAPP transgenic mouse islets.
@en
P2093
J Udayasankar
M V Faulenbach
S L Subramanian
P2860
P2888
P304
P356
10.1007/S00125-008-1185-7
P577
2008-11-11T00:00:00Z