about
Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendationsA primer on systematic reviews in toxicology."ToxRTool", a new tool to assess the reliability of toxicological data.Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review.The Emergence of Systematic Review in Toxicology.Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods.A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.Categorization of chemicals according to their relative human skin sensitizing potency.Validation study on the Ocular Irritection assay for eye irritation testing.Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.Prospective multicentre study of the U-SENS test method for skin sensitization testing.Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility.LLNA variability: An essential ingredient for a comprehensive assessment of non-animal skin sensitization test methods and strategies.Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods.Mechanistic validation.Simple clotting test to detect procoagulant abdominal swabs.Integrated Testing Strategies (ITS) for safety assessment.A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals.Evidence-Based Toxicology.State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop.Round robin study to evaluate the reconstructed human epidermis (RhE) model as an in vitro skin irritation test for detection of irritant activity in medical device extracts.Non-animal methods to predict skin sensitization (II): an assessment of defined approaches *.Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database.Toward Good In Vitro Reporting StandardsEstimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats1.2 Aspects of test assessmentExposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicityThe HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-lab reproducibility and predictivityValidation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particlesAdaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity TestThe GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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Sebastian Hoffmann
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