A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.
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Teaching experimental designReview: toxicometabolomicsDevelopmental neurotoxicity - challenges in the 21st century and in vitro opportunitiesLook back in anger - what clinical studies tell us about preclinical workA New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using ZebrafishAnalysis of publically available skin sensitization data from REACH registrations 2008-2014Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testingReference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades.Mapping the human toxome by systems toxicology.The human toxome projectThe usefulness of systematic reviews of animal experiments for the design of preclinical and clinical studies.The relevance and potential roles of microphysiological systems in biology and medicineProfiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test batteryHigh content analysis of an in vitro model for metabolic toxicity: results with the model toxicants 4-aminophenol and cyclophosphamide.Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture.A probabilistic model of human variability in physiology for future application to dose reconstruction and QIVIVE.A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk.Metabolomics in toxicology and preclinical research.FutureTox: building the road for 21st century toxicology and risk assessment practicesDesign principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.Systems toxicology: from basic research to risk assessment.Dendritic cells and the assessment in vitro of skin sensitizing potential.The role of in vitro methods as alternatives to animals in toxicity testing.Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development.Predicting the carcinogenicity of chemicals with alternative approaches: recent advances.Hexyl cinnamal: consideration of skin-sensitizing properties and suitability as a positive control.Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach.A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions.The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Prenatal exposure to environmental factors and congenital limb defects.Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy.Integrated testing strategies for safety assessments.Adverse outcome pathways: opportunities, limitations and open questionsToxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.Mechanistic validation.Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
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A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
A roadmap for the development ...... toxicity testing - t4 report*.
@en
A roadmap for the development of alternative
@nl
type
label
A roadmap for the development ...... toxicity testing - t4 report*.
@en
A roadmap for the development of alternative
@nl
prefLabel
A roadmap for the development ...... toxicity testing - t4 report*.
@en
A roadmap for the development of alternative
@nl
P2093
P50
P356
P1476
A roadmap for the development ...... for systemic toxicity testing
@en
P2093
Alan Goldberg
Andreas Schepky
Annamaria Rossi
Chantra Eskes
Costanza Rovida
David A Basketter
Emily A McVey
Erwin Roggen
Gavin Maxwell
Gladys Ouédraogo
P356
10.14573/ALTEX.2012.1.003
P577
2012-01-01T00:00:00Z