Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2
about
Integrated analysis of residue coevolution and protein structure in ABC transportersABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRObligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerizationConserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingCysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.The CFTR ion channel: gating, regulation, and anion permeationLong-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsConverting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsConformational changes in the catalytically inactive nucleotide-binding site of CFTR.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter
P2860
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P2860
Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@en
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@nl
type
label
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@en
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@nl
prefLabel
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@en
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@nl
P2860
P50
P356
P1476
Involvement of F1296 and N1303 ...... esponse to ATP binding at NBD2
@en
P2860
P304
P356
10.1085/JGP.201010434
P577
2010-10-01T00:00:00Z