Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. - Wikidata - awgldk - TriplyDB

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

http://www.wikidata.org/entity/Q42434602

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A palmitoylation switch mechanism regulates Rac1 function and membrane organization.Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins Structural Mechanisms and Drug Discovery Prospects of Rho GTPases Rho GTPases, oxidation, and cell redox control Rho GTPase regulation by miRNAs and covalent modifications RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.A new genetically encoded single-chain biosensor for Cdc42 based on FRET, useful for live-cell imaging An isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant species Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells Regulation of Rac1 translocation and activation by membrane domains and their boundaries.Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis.RhoB regulates cell migration through altered focal adhesion dynamics.Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.Molecular dynamic simulation reveals damaging impact of RAC1 F28L mutation in the switch I region.Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferase Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling CYK-4 regulates Rac, but not Rho, during cytokinesis.Small G proteins in islet beta-cell function.Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.Regulation of cerebral cortex development by Rho GTPases: insights from in vivo studies.Differentiation-dependent PTPIP51 expression in human skeletal muscle cell culture.Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells.Function and regulation of Rnd proteins in cortical projection neuron migration

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P2860

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

http://www.wikidata.org/entity/Q42434602

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Rho Family GTPase modification ...... osttranslational modification.

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Rho Family GTPase modification ...... osttranslational modification.

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type

label

Rho Family GTPase modification ...... osttranslational modification.

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Rho Family GTPase modification ...... osttranslational modification.

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Rho Family GTPase modification ...... osttranslational modification.

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Rho Family GTPase modification ...... osttranslational modification.

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Journal of Biological Chemistry

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Rho Family GTPase modification ...... osttranslational modification.

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P2093

Adrienne D Cox

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Channing J Der

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Emily J Chenette

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James P Madigan

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Natalia Mitin

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Oswald Wilson

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Patricia J Keller

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Patrick J Roberts

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Paul Kirschmeier

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Rachel O Currin

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P2860

The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

Post-translational modifications of p21rho proteins

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

Rho GTPases have diverse effects on the organization of the actin filament system

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

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25150-25163

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scholarly article

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10.1074/JBC.M800882200

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P433

37

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P478

283

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2008-07-09T00:00:00Z

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18614539

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2533093

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