First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone - Wikidata - awgldk - TriplyDB

First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone

First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone

http://www.wikidata.org/entity/Q42445249

about

Alternatives to currently used antimalarial drugs: in search of a magic bullet Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs Anticancer properties of distinct antimalarial drug classes Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.Artemisone effective against murine cerebral malaria Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax Antimalarial compounds in Phase II clinical development.Artemisone uptake in Plasmodium falciparum-infected erythrocytes.Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria The global pipeline of new medicines for the control and elimination of malaria Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Artemether-lumefantrine: an oral antimalarial for uncomplicated malaria in children.Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy.Artemisinin derivatives: a patent review (2006 - present).Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.Novel anti-malarial combinations and their toxicity.Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria.Controlled release of artemisone for the treatment of experimental cerebral malaria.In vivo and in vitro antimalarial activity of 4-nerolidylcatechol.Endoperoxide Drug Cross-Resistance Patterns for Plasmodium falciparum Exhibiting an Artemisinin Delayed-Clearance Phenotype.In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents.Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro.The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone.Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication

P2860

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P2860

First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone

http://www.wikidata.org/entity/Q42445249

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2008 nî lūn-bûn

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First assessment in humans of ...... emisinin derivative artemisone

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Antimicrobial Agents and Chemotherapy

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First assessment in humans of ...... emisinin derivative artemisone

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P2093

Axel Roemer

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Barbara M Kotecka

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Barbara Voith

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Burkhard Fugmann

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Georg Wensing

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Johannes Nagelschmitz

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Karl H Rieckmann

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Michael D Edstein

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P2860

Antimalarial drug resistance

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

Multiple dose study of interactions between artesunate and artemisinin in healthy volunteers

Synchronization of Plasmodium falciparum erythrocytic stages in culture

Neurotoxicity of artemisinin analogs in vitro.

Artemisinin drugs: novel antimalarial agents.

Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens

Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria.

The assessment of antimalarial drug efficacy.

Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review.

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3085-3091

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scholarly article

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10.1128/AAC.01585-07

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9

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52

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Richard K Haynes

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2008-06-16T00:00:00Z

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18559649

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2533467

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