Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. - Wikidata - awgldk - TriplyDB

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

http://www.wikidata.org/entity/Q42459963

about

Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals Leptin signaling and leptin resistance Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis FoxO1 target Gpr17 activates AgRP neurons to regulate food intake Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3 Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis Mechanism of attenuation of leptin signaling under chronic ligand stimulation.Hyperleptinemia is required for the development of leptin resistance.Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin.Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.Involvement of hypothalamic PI3K-STAT3 signalling in regulating appetite suppression mediated by amphetamine.Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system.Leptin in human physiology and therapeutics Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice 20 years of leptin: connecting leptin signaling to biological function The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.Expression of suppressor of cytokine signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury Hyperphagia and leptin resistance in tissue inhibitor of metalloproteinase-2 deficient mice.Melanocortin control of energy balance: evidence from rodent models.Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender.Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance.Leptin and the central nervous system control of glucose metabolism.Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation.Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.Leptin regulation of Hsp60 impacts hypothalamic insulin signaling T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.Central insulin and leptin-mediated autonomic control of glucose homeostasis.Metabolic influences on neuroendocrine regulation of reproduction.Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions.The Leptin Receptor Complex: Heavier Than Expected?

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P2860

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

http://www.wikidata.org/entity/Q42459963

description

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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Enhanced Stat3 activation in P ...... insulin signaling in obesity.

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JNEUROSCI.5712-08.2009

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Andreas Husch

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Brigitte Hampel

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Claudia M Wunderlich

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F Thomas Wunderlich

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Heike Münzberg

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Jens Alber

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Jens C Brüning

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