Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
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Mouse models of polyglutamine diseases: review and data table. Part ISystems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor SystemA Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.Altered hypothalamic protein expression in a rat model of Huntington's diseaseMaintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunctionEffects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington diseaseHuntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sortingMutant huntingtin impairs immune cell migration in Huntington disease.A fully humanized transgenic mouse model of Huntington disease.Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.Volumetric analysis of the hypothalamus in Huntington Disease using 3T MRI: the IMAGE-HD Study.Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington diseaseExpression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouseBone marrow transplantation confers modest benefits in mouse models of Huntington's disease.Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Partial Amelioration of Peripheral and Central Symptoms of Huntington's Disease via Modulation of Lipid Metabolism.Intrajugular vein delivery of AAV9-RNAi prevents neuropathological changes and weight loss in Huntington's disease mice.Mitochondrial and metabolic-based protective strategies in Huntington's disease: the case of creatine and coenzyme Q.Hypothalamic alterations in Huntington's disease patients: comparison with genetic rodent models.Preclinical models: needed in translation? A Pro/Con debate.Body weight is a robust predictor of clinical progression in Huntington disease.Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1.Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease.Autophagy in the control of food intake.Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease.Reduced motivation in the BACHD rat model of Huntington disease is dependent on the choice of food deprivation strategyGene suppression approaches to neurodegeneration.Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.Systemic stress signalling: understanding the cell non-autonomous control of proteostasis.Overlap between age-at-onset and disease-progression determinants in Huntington disease.
P2860
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P2860
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@en
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@nl
type
label
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@en
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@nl
prefLabel
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@en
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@nl
P2093
P1433
P1476
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
@en
P2093
Bengt F Belgardt
Deniz Kirik
Rana Soylu
Sofia Hult
Tomas Björklund
Åsa Petersén
P304
P356
10.1016/J.CMET.2011.02.013
P577
2011-04-01T00:00:00Z