Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
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Mouse models of polyglutamine diseases: review and data table. Part IMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceCaspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates.Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's diseasePhosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer diseaseAn Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal ModelSUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.PolyQ disease: misfiring of a developmental cell death program?Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity.Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.Palmitoylation of caspase-6 by HIP14 regulates its activation.Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic.Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease
P2860
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P2860
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
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2012 nî lūn-bûn
@nan
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
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name
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@ast
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
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type
label
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@ast
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@en
prefLabel
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@ast
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@en
P2093
P2860
P50
P1476
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
@en
P2093
Deborah Swing
Elaine Waldron-Roby
Erin Watkin
Lino Tessarollo
Mali Jiang
Mikhail Pletnikov
Nikolas Arbez
Rona K Graham
Tamara Ratovitski
Wenzhen Duan
P2860
P304
P356
10.1523/JNEUROSCI.1305-11.2012
P407
P577
2012-01-01T00:00:00Z