Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activation.
about
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitationCalmodulin-dependent protein kinase II: linking heart failure and arrhythmiasModern concepts concerning the origin of the heartbeat.Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node CellsThe importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeatStimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C)Ca²⁺-dependent phosphorylation of Ca²⁺ cycling proteins generates robust rhythmic local Ca²⁺ releases in cardiac pacemaker cells.Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Aging and CaMKII alter intracellular Ca2+ transients and heart rhythm in Drosophila melanogaster.alpha1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes.Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cellsElectrophysiological remodeling in heart failureA novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cellsCa²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics.Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.From two competing oscillators to one coupled-clock pacemaker cell systemStore-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells.CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.Modern perspectives on numerical modeling of cardiac pacemaker cellWhat keeps us ticking: a funny current, a calcium clock, or both?Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cellsRhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cellsAtrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signalCa(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2-independent mechanisms, unlike muscular dystrophyExpression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticity.Nonlinear dynamics in cardiology.The missing link in the mystery of normal automaticity of cardiac pacemaker cells.Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.Calmodulin kinase II is required for fight or flight sinoatrial node physiologyGenesis and regulation of the heart automaticity.Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels.Beta-adrenergic receptor signaling in the heart: role of CaMKII.
P2860
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P2860
Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activation.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Sinoatrial node pacemaker activity requires Ca
@nl
Sinoatrial node pacemaker acti ...... protein kinase II activation.
@en
type
label
Sinoatrial node pacemaker activity requires Ca
@nl
Sinoatrial node pacemaker acti ...... protein kinase II activation.
@en
prefLabel
Sinoatrial node pacemaker activity requires Ca
@nl
Sinoatrial node pacemaker acti ...... protein kinase II activation.
@en
P2093
P356
P1433
P1476
Sinoatrial node pacemaker acti ...... protein kinase II activation.
@en
P2093
Bogdanov KY
Vinogradova TM
P304
P356
10.1161/01.RES.87.9.760
P577
2000-10-01T00:00:00Z