Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.
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Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with AktEphA2 is an essential mediator of UV radiation-induced apoptosisSoluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptorLigand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complexEphA receptor signaling--complexity and emerging themesFrom Normal Skin to Squamous Cell Carcinoma: A Quest for Novel BiomarkersEPHA2 is associated with age-related cortical cataract in mice and humansCapillary defects and exaggerated inflammatory response in the airways of EphA2-deficient miceVariable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cellsThe receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signalingEphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.Anti-EphA2 Antibodies with Distinct In Vitro Properties Have Equal In Vivo Efficacy in Pancreatic Cancer.Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia.EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.Soluble ephrin a1 is necessary for the growth of HeLa and SK-BR3 cellsA small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.Skin as a living coloring book: how epithelial cells create patterns of pigmentation.Emerging strategies for EphA2 receptor targeting for cancer therapeutics.A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.Eph/ephrin signaling in epithelial development and homeostasisClinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling.EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes.EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration.Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.Eph/ephrin signaling in epidermal differentiation and diseaseEph receptor and ephrin function in breast, gut, and skin epithelia.Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma.Proteolysis of EphA2 Converts It from a Tumor Suppressor to an OncoproteinNMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis.Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases.EphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo studyEffects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer.Eph receptors in breast cancer: roles in tumor promotion and tumor suppression.Roles of EphA2 in Development and Disease.Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery.
P2860
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P2860
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@en
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@nl
type
label
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@en
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@nl
prefLabel
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@en
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@nl
P2093
P1433
P1476
Disruption of EphA2 receptor t ...... carcinogenesis in mouse skin.
@en
P2093
Anita C Gilliam
Bingcheng Wang
Jarnail Singh
Lizabeth Gerber
Mitchell F Denning
P304
P356
10.1158/0008-5472.CAN-06-0004
P407
P577
2006-07-01T00:00:00Z