A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.

A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.

Item
http://www.wikidata.org/entity/Q42511858
Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilageAggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairEvidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.Mapping Chondrocyte Viability, Matrix Glycosaminoglycan, and Water Content on the Surface of a Bovine Metatarsophalangeal Joint."Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.
P2860

A cartilage explant system for studies on aggrecan structure, biosynthesis and catabolism in discrete zones of the mammalian growth plate.

Item
http://www.wikidata.org/entity/Q42511858
description
1993 nî lūn-bûn
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1993年の論文
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1993年学术文章
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1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
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1993年學術文章
@yue
1993年學術文章
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1993年學術文章
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name
A cartilage explant system for ...... of the mammalian growth plate.
@en
A cartilage explant system for ...... of the mammalian growth plate.
@nl
type
label
A cartilage explant system for ...... of the mammalian growth plate.
@en
A cartilage explant system for ...... of the mammalian growth plate.
@nl
prefLabel
A cartilage explant system for ...... of the mammalian growth plate.
@en
A cartilage explant system for ...... of the mammalian growth plate.
@nl
P1433
P1476
P2093
P304
P31
P433
P478
P577
P698
P921
P1433
P1476
A cartilage explant system for ...... of the mammalian growth plate.
@en
P2093
P304
P31
P433
P478
P577
P698
P921