The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
about
Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblastsCaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophyNuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cellsHistone deacetylase signaling in cardioprotectionCaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitationSignaling effectors underlying pathologic growth and remodeling of the heartNew therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)CaMKIIdelta subtypes: localization and functionClass II histone deacetylases act as signal-responsive repressors of cardiac hypertrophyMolecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytesmiR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathwaysAAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failureHistone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart developmentLocation matters: clarifying the concept of nuclear and cytosolic CaMKII subtypesRegulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2ACaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heartOxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.Loss of MD1 exacerbates pressure overload-induced left ventricular structural and electrical remodelling.Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptorCaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Left ventricular and aortic dysfunction in cystic fibrosis mice.Thyroid Hormone-Regulated Cardiac microRNAs are Predicted to Suppress Pathological Hypertrophic Signaling.CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathyMyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction.Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity.CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling.Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis.QT interval prolongation and arrhythmia: an unbreakable connection?Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling.Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB.Beta-adrenergic pathways in human heart failure.Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases.Global comparison of phosphoproteins in human and rodent hearts: implications for translational studies of myosin light chain and troponin phosphorylations.Is CaMKII a link between inflammation and hypertrophy in heart?Toward biologically targeted therapy of calcium cycling defects in heart failure.Sex modifies exercise and cardiac adaptation in miceThe delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
P2860
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P2860
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The cardiac-specific nuclear delta
@nl
The cardiac-specific nuclear d ...... otein phosphatase 2A activity.
@en
type
label
The cardiac-specific nuclear delta
@nl
The cardiac-specific nuclear d ...... otein phosphatase 2A activity.
@en
prefLabel
The cardiac-specific nuclear delta
@nl
The cardiac-specific nuclear d ...... otein phosphatase 2A activity.
@en
P2093
P2860
P356
P1476
The cardiac-specific nuclear d ...... otein phosphatase 2A activity.
@en
P2093
Darrell D Belke
Eric N Johnson
Howard Schulman
Joan Heller Brown
Marisa S Gigena
Michael R Morissette
Terry B Rogers
Tong Zhang
Valerie P Sah
P2860
P304
P356
10.1074/JBC.M108525200
P407
P577
2001-11-02T00:00:00Z